I'd buy all singles. You know what you're getting and although it's not as fun, It won't be such a let down. It's hard for me to spend 100 on a box and get a bunch of stuff I don't really want. But its easy for me to say that because i don't collect any new sets. (see my signature) so the new stuff just all goes up for trade and its hard to trade base. It just sits until i donate it. So if you're looking to build a set, buy a box. If not, buy singles.
Looking for: Brandon Nolan, Manon Rheaume
Trilogy Ice Scripts / Ultimate Collection Premium Patches
2011-12 Upper Deck Ice / 2008-09 Upper Deck Ice
1995-96 Bowman / 1995-96 Select Certified / 1995-96 Playoff 1 on 1
2014-15 Upper Deck MVP / 2005-06 Upper Deck Ice Fresh Ice Patches
Trilogy Ice Scripts / Ultimate Collection Premium Patches
2011-12 Upper Deck Ice / 2008-09 Upper Deck Ice
1995-96 Bowman / 1995-96 Select Certified / 1995-96 Playoff 1 on 1
2014-15 Upper Deck MVP / 2005-06 Upper Deck Ice Fresh Ice Patches